Symbol
Name
ID

Plcg2
phospholipase C, gamma 2
MGI:97616

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Mouse Phenotypes

increased B cell apoptosis

abnormal osteoclast differentiation

abnormal dendritic cell chemotaxis

decreased B cell proliferation

increased B cell proliferation

impaired macrophage phagocytosis

spleen hyperplasia

abnormal B cell differentiation

decreased transitional stage B cell number

increased immature B cell number

increased transitional stage T2 B cell number

increased pro-B cell number

arrested B cell differentiation

decreased mature B cell number

decreased B-1a cell number

decreased B-2 B cell number

decreased follicular B cell number

increased B-1a cell number

decreased pre-B cell number

increased pre-B cell number

increased effector memory CD8-positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased osteoclast cell number

abnormal dendritic cell morphology

abnormal B cell physiology

decreased IgM level

abnormal NK cell physiology

impaired natural killer cell mediated cytotoxicity

decreased platelet aggregation

Availability

Mouse Genotype

Plcg2^Ali5/Plcg2^Ali5

Plcg2^em1Msasn/Plcg2^em1Msasn

Plcg2^m1Btlr/Plcg2^m1Btlr

Plcg2^M3Btlr/Plcg2^M3Btlr

Plcg2^m4Btlr/Plcg2^m4Btlr

Plcg2^tm1.1Kuro/Plcg2^tm1.1Kuro

Plcg2^tm1Jni/Plcg2^tm1Jni

Plcg2^Ali5/Plcg2⁺

Plcg2^tm1Kuro/Plcg2^tm1Kuro
Tg(Mx1-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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